Wim Henderickx studied composition and percussion at the Royal Conservatoire of Music in Antwerp. He repeatedly took part in the Internationale Ferienkurse für Neue Musik in Darmstadt and attended sonology classes at Ircam in Paris and at the Royal Conservatory of Music in The Hague.
Since 1996, Henderickx is composer in residence at Muziektheater Transparant, an international production company for music theatre based in Antwerp. In August 2013 he became artist in residence at the Royal Flemish Philharmonic (deFilharmonie). Henderickx teaches composition and music analysis at the Conservatories in Antwerp and Amsterdam. At the annual summer composition course Soundmine for young composers, organised by Musica, Impulse Centre for Music, he is the main teacher.
Henderickx received different prizes, among which the Lifetime Achievement culture prize at his native city Lier in 2011. His scores are published by Norsk Musikforlag in Oslo.