AMUZ is an international music centre, hosting cultural, educational and research activities. The concert programme of AMUZ is inspired by the criteria of Historically Informed Performance (HIP): on the basis of a historically valid approach, music from all periods, styles and cultures is presented to a broad public in an accessible way. Often music also engages in a dialogue with the other arts. In order to achieve this, AMUZ can take advantage of a baroque monument, the former church of St Augustine, adapted with advanced technology.

AMUZ integrates other historical buildings of the city of Antwerp as venues, more specifically during the events organized in the framework of the Flanders Festival-Antwerp. In addition to its concerts, AMUZ organises the Laus Polyphoniae festival.