Guido De Neve was accepted as a pupil at the Royal Conservatory of Brussels at the age of 11. From that early age he was performing regular concerts in chamber music and as a soloist with orchestra. In 2004, De Neve started to perform on historical instruments. A new dimension of research in music, sound, phrasing and much more was born.

Today Guido De Neve plays the Baroque violin, classical-romantic violin and the modern violin in order to explore the sound worlds of old and modern instruments. Results of this research are for example the recording of the complete Bach Sonatas with harpsichord (Frank Agsteribbe). This recording was praised for its outstanding performance and its groundbreaking approach. A highlight on the romantic violin was the discovery and recording of César Franck’s second violin sonata.

In 2019, he founded Quatuor Romantique, a string quartet playing in romantic style on romantic instruments. All his research resulted in the discovery of many manuscripts among Lekeu, Litta, van Maldere, Franck and De Boeck.

Guido De Neve has been a violin teacher for more than 25 years, and head of the violin departement from the Royal Conservatoire of Antwerp.