Piet Kuijken is a student of Jan Vermeulen; he studied at the Royal Conservatory in Brussels under Jan Michiels, Arie van Lysebeth and André De Groote. He graduated with the highest honours from the piano and chamber music classes. He has appeared at solo recitals, played with chamber ensembles and orchestras under the baton of conductors such as Avim Ostrovski, Zeeve Dorman, Robert Groslot, Norbert Nozy, Etienne Siebens, Silveer van den Broeck, Robert Casteels and Wieland Kuijken. He has performed in many European countries, as well as Japan and the United States. His wide repertoire spans from the Baroque to modern music; he performs on the harpsichord, pianos of various historical periods, and on modern instruments.

Since 1988, Kuijken has been linked with the Prometheus Ensemble, and has appeared in duos with pianist Bart Meynckens, clarinettist Henk Soen, cellist Karel Steylaerts, and his father Wieland Kuijken. He has also on numerous occasions played with the Oxalys, Ictus and Ensor ensembles, as well as Anne Cambier, Olga Pasiecznik, His discography includes works by Luc van Hove, the chamber works of Debussy, as well as the complete viola da gamba sonatas of Johann Sebastian Bach. With Karel Steylaerts, he recorded the complete cello and piano works of Joseph Jongen.