The MP4 Quartet was created in 2008 by four young graduates of the Royal Conservatories of Belgium. They steer their work in supporting new creations as well as performing classical masterpieces. They gained experience and freedom of expression at the Orpheus Institute of Ghent and with the Danel, Pavel Haas, Pražák and Kronos quartets.

In the 2014 season, the MP4 Quartet created the "Steve Reich project”: a show around Reich’s creations, alongside the choreographer Isabella Soupart. With composer Pierre Slinckx they created and recorded M#1 for string quartet and electronics in 2019, for which they received an “Octave de la Musique” in the contemporary section (2020) from the Fédération Wallonie-Bruxelles.